Hatter Cardiovascular Institute, London, United Kingdom; Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom. Hatter Cardiovascular Institute, London, United Kingdom; Charité - Universitätsmedizin Berlin, Germany. London School of Hygiene and Tropical Medicine, London, United Kingdom. Essex Cardiothoracic Centre, Basildon, United Kingdom. Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom. Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom. Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom. Hatter Cardiovascular Institute, London, United Kingdom; Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, United Kingdom; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore; Yong Loo Lin School of Medicine, National University Singapore, Singapore; Tecnologico de Monterrey, Centro de Biotecnologia-FEMSA, Nuevo Leon, Mexico. Electronic address: derek.hausenloy@duke-nus.edu.sg.